Regulated Expression and Function of CD 122 ( Interleukin - 2 / Interleukin - l 5 R - ~ ) During Lymphoid Development
نویسندگان
چکیده
TO determine whether signaling via CD122 (interleukin-2 [IL21/IL-15 receptor p-chain) plays a role in regulating the expansion and differentiation of lymphocyte precursors, we have characterized its expression and evaluated its ability to influence the activity of developing lymphoid cells. A significant fraction of Scal'Linhematopoietic stem cells in day 12 fetal liver were found to be CD122+. CD122-mRNA+ and IL-2-mRNA' cells were also localized in embryo sections within pharyngeal blood vessels adjacent to and surrounding the thymic analgen. This distribution is consistent with the migration of CD122+ progenitor cells from the liver to the developing thymus where a majority of Scal' intra-
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